![]() This incited us to set up an open-source freely available semi-automated solution to measure parameters like trabecular area, osteoid area, trabecular thickness, and osteoclast activity. However, until today, to our knowledge, bone histomorphometry remain time-consuming and expensive. Besides, quantitative evaluation plays an important role in fracture healing studies to explore the effect of biomaterial or drug treatment. Histomorphometry plays an important role in monitoring changes in bone properties because of systemic skeletal diseases like osteoporosis and osteomalacia. 3Department of Computer Science and Artificial Intelligence, Basque Country University, San Sebastian, Spainīone histomorphometry allows quantitative evaluation of bone micro-architecture, bone formation, and bone remodeling by providing an insight to cellular changes. ![]() 2Department of Trauma, Hand, and Reconstructive Surgery, University Hospital of Giessen and Marburg, Giessen, Germany.1Experimental Trauma Surgery, Faculty of Medicine, Justus-Liebig University of Giessen, Giessen, Germany.Schaefer 1, Felix Merboth 1, David Weisweiler 1,2, Christian Heiss 1,2, Ignacio Arganda-Carreras 3 * and Thaqif El Khassawna 1 * Deeksha Malhan 1, Matthias Muelke 1,2, Sebastian Rosch 1, Annemarie B.
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